PIUG Biotech 2023 - Plenary

16

PIUG 2023 Biotechnology Conference

 A F T E R N O O N S P E A K E R S

Searching Chemically Modified siRNA – Mission Impossible? Anne Marie Clark, CAS IP Services and BarbaraMiller, Amgen 2:00 – 2:30 pm

 ABSTRACT Short, inhibitory RNAs (siRNA) can be challenging to search due to their size and chemical modifications. While procedures have been developed to maximize siRNA sequence searching based on the sequence length, processes for searching siRNA by chemical modifications are still being developed. Chemically modified siRNAs are increasingly important and can be claimed by sequence and/or chemical modification patterns, without mention of the siRNA target. Due to the various ways siRNAs can be claimed and the different search procedures involved, performing FTO searches can be complex and time-consuming. This talk will cover the general considerations for siRNA searches, but will focus on the new searching techniques being developed for siRNA and other short sequences with chemical modifications. Utilizing the unique data on chemically modified siRNAs available in CAS REGISTRY, methods for searching and analyzing siRNA chemical modification patterns using KNIME and Microsoft Excel will be described.  BIOGRAPHIES Anne Marie Clark is a Senior Scientist with CAS IP Services, part of CAS, a division of the American Chemical Society. Prior to joining CAS in 2016, she was an independent searcher, a Manager of Intellectual Property with Bausch & Lomb, an Associate Director-Information Science at Pfizer, and an Information Scientist with CAS. She has a Ph.D. in biophysical chemistry from University of Louisville, a Drug Development certificate from Temple University and a B.S. in chemistry from Rochester Institute of Technology. In her free time, she mentors FIRST Robotics teams, gardens and explores the Pacific Northwest. Barbara Miller is currently a Patent and Scientific Analyst in the Amgen IP Law group. Prior to joining Amgen in 2017, she was a Patent and Scientific Analyst at the Novartis Institutes for Biomedical Research (NIBR) in Cambridge, MA, and an Information Scientist at Pfizer in Groton, CT. She has a Ph.D. in Biological Sciences from Emory University in Atlanta, GA, a M.S. in Regulatory Affairs and Quality Assurance from Temple University, and a B.S. in Chemistry from Rhodes College in Memphis, TN. In her free time, she enjoys reading, traveling, cycling, yoga, and finding unusual restaurants and shops.